Patrice Motsepe was born in Soweto in 1962, trained as a lawyer at the University of Swaziland and the University of the Witwatersrand and became, in 1994, the first Black African partner at the law firm Bowman Gilfillan. He founded African Rainbow Minerals in 1997 by acquiring marginal gold mines and built it into one of South Africa's most significant diversified mining companies.

He has since extended his holdings into financial services through African Rainbow Capital and into renewable energy, and serves as president of the Confederation of African Football. He is also a substantial philanthropist through the Motsepe Foundation, having committed at least half of his family's wealth to charitable work through the Giving Pledge.